Inter vs Sassuolo: Match Prediction , Preview, Lineups, H2h for September 22, 2025

This Sunday, Serie A features a match at the San Siro in Milan, where Inter will take on Sassuolo. There’s a good chance for plenty of goals in this game.

Match preview

Inter began the season strongly with a big win over Torino but then faced unexpected setbacks in two consecutive matches. In their recent game against Juventus, they displayed strong attacking skills but faltered defensively, conceding two late goals that led to a loss. Despite this, Inter remains the top-scoring team in the league after three rounds.

At home, Inter has been impressive offensively, scoring at least three goals in their last two matches, although they haven’t secured a win. However, their defense needs improvement, as they are allowing too many goals. If they want to win this match, tightening their defense is crucial.

Sassuolo recently broke a long winless streak in Serie A with a close victory over Lazio. Under Fabio Grosso, they played carefully, clinching the win with an early goal and solid defending. Still, they face challenges on away trips this season.

On the road, Sassuolo often concedes goals but usually manages to score as well. In their last five away games, they have scored in every match, including twice against Cremonese in their first game. In past encounters with Inter at the San Siro, Sassuolo has consistently found the net, scoring ten goals in their last five visits.

Probable lineups

• Inter: Sommer, Akanji, Acerbi, Bastoni, Dumfries, Mkhitaryan, Barella, Calhanoglu, Augusto, Lautaro, Thuram
• Sassuolo: Muric, Doig, Muharemovic, Idzes, Walukiewicz, Matic, Kone, Vranckx, Laurienté, Pinamonti, Berardi

Match facts and head-to-head

• Six of Inter’s last eight home Serie A matches have had three or more goals.
• Sassuolo has scored in their last five away games.
• Sassuolo has found the net in each of their last five away matches against Inter.

Prediction

Both teams enter this match with strong attacking capabilities but have shown defensive vulnerabilities. The visitors are consistent scorers, especially away, and can challenge Inter’s defense. Our recommendation: “Both teams to score” at odds of 2.03.