Inter vs Sassuolo: Predictions , Preview, Lineups, H2h for September 22, 2025

On Sunday, September 21, 2025, Serie A’s fourth round features an important match as Inter takes on Sassuolo at home. Kick-off is scheduled for 20:45 Central European Time. Here’s a look at what to expect in this game.

Inter

Inter enters this match after a successful Champions League game, where they defeated Ajax 2-0 at home, ending a two-game losing streak in the league. They started their Serie A campaign strong with a 5-0 win over Torino but experienced setbacks with a 1-2 loss to Udinese and a 3-4 defeat to Juventus. After three matches, Inter has earned just 3 points and currently ranks 11th in the standings, not meeting the club’s expectations.

In their last six encounters at Giuseppe Meazza, both Inter and Sassuolo have won twice, with two matches ending in draws. Four of those six games saw more than 2.5 goals scored, and both teams scored in four matches as well. Inter is looking to improve, especially after losing to Sassuolo in their last home match in 2023.

Sassuolo

Sassuolo returned to Serie A after winning Serie B last season. They started their new campaign with a narrow 1-0 win against Catanzaro in the Coppa Italia. However, their Serie A performance has been uneven. They lost their first home game 0-2 to Napoli and then fell 2-3 away to Cremonese. Finally, they won 1-0 against Lazio in their third match. Sassuolo also has 3 points after three games but is placed 14th in the table.

Sassuolo’s recent history against Inter is intriguing; they have won the last two meetings, and in their last six matchups, each side has three victories.

Probable lineups

• Inter: Sommer, Bisseck, Acerbi, Bastoni, Dumfries, Sučić, Barella, Çalhanoğlu, Dimarco, Frattesi, Thuram.
• Sassuolo: Muric, Doig, Muharemović, Idzes, Koulibaly, Matić, Koné, Vranckx, Laurienté, Pinamonti, Berardi.

Key facts and head-to-head stats

• Three of Inter’s last four matches have had over 2.5 goals.
• Inter has scored first in four of their last five games.
• Five of Sassuolo’s last six matches have ended with under 2.5 goals.
• Inter has opened the scoring in four of their last five head-to-head matches.

Prediction for Inter vs Sassuolo

Inter is eager to make a comeback after two Serie A losses, especially in front of their home crowd following a strong Champions League victory. Past losses to Sassuolo add extra motivation. Inter is favored to win this match, and an attacking display is likely. My prediction: Inter to win with a -1.5 handicap at odds of 1.74.