Jannik Sinner Takes on Lorenzo Musetti: Predictions and Betting Tips for September 4, 2025

The US Open quarterfinals will see Jannik Sinner face Lorenzo Musetti in an all-Italian match. Here’s a look at the key points for this upcoming game.

Jannik Sinner

Sinner’s season has had its challenges, including a suspension and a breakup. However, his tennis performance has been impressive. The world number one has won two Grand Slam titles this year, taking top honors at both the Australian Open and Wimbledon, and finished as a runner-up at the French Open, where he narrowly missed several match points in the final.

At the US Open, Sinner’s only real test came against Shapovalov in the third round, which he won 5:7, 6:4, 6:3, 6:3. He won easily against his other opponents, defeating Kopriva 6:1, 6:1, 6:2; Popyrin 6:3, 6:2, 6:2; and Bublik 6:1, 6:1, 6:1. As the defending US Open champion, Sinner appears determined to retain his title.

Lorenzo Musetti

Musetti has had a solid season, breaking into the top 10 and currently ranked tenth in the world. However, he hasn’t won any titles this year. He advanced to the semifinals at Roland Garros, Rome, and Madrid, and reached the final in Monte Carlo, but lost to Carlos Alcaraz in three of those four events.

Musetti’s toughest match in this tournament was in the first round against French player Mpetshi Perricard, which he won 6:7, 6:3, 6:4, 6:4. After that, he won convincingly against Goffin 6:4, 6:0, 6:2; defeated Cobolli 6:3, 6:2, 2:0 due to retirement; and dominated Spain’s Munar 6:3, 6:0, 6:1 in his last match.

Match facts

• Sinner has won 16 of 17 matches on hard courts this season.
• Musetti has 11 wins from 18 hard court matches in 2025.
• Current odds from bookmakers: Sinner to win – 1.04; Musetti to win – 12.25.

H2H

Sinner leads their head-to-head record 2-1, with Musetti’s only win coming when Sinner retired mid-match.

Prediction

In this Italian matchup, Sinner is the clear favorite. While Musetti may put up some resistance, winning seems unlikely. Sinner has excelled on hard courts, making him a tough opponent on this surface. Expect to see him win with a -7 game handicap.