Liverpool vs Southampton: Match Predictions , Preview, Lineups, H2h for September 24, 2025

On Tuesday, Anfield in Liverpool will host a Carabao Cup match between Liverpool and Southampton. This match presents a good betting opportunity based on current form.

Match preview

Liverpool, managed by Arne Slot, is having a fantastic season, with six consecutive wins in all competitions. They are at the top of the Premier League and have consistently strong attacking stats, scoring in every match and achieving 39 consecutive league games with goals. However, their defense has shown some vulnerabilities, letting a 2-0 lead slip three times. In cup matches, Liverpool often steps up their game, and their squad depth enables them to maintain high performance levels even with player rotation.

Younger players will play a key role in this matchup: Trey Nyoni might debut in midfield, while Federico Chiesa is expected to lead the attack. Mamardashvili is likely to start in goal, looking to impress with his composure. Despite an experimental lineup, Anfield remains a tough venue for visiting teams.

Southampton is struggling near the bottom of the Championship, currently in 19th place. Under Will Still’s management, they recently lost to Hull (1-3) and have secured only one win in their last six matches. While the squad has talent, they have difficulties in finishing and defensive organization. Nonetheless, Southampton often performs well in cup competitions, having reached the quarterfinals last season, and will be looking to seize any chance they get.

Against Liverpool, Southampton will likely adopt a three-central-defender setup to withstand pressure. However, even this formation may not protect them from the hosts’ speed and relentless pressing. Players like Downes and Stephens will need to lead, but facing Liverpool at Anfield in their current condition poses a significant challenge.

Probable lineups

• Liverpool: Mamardashvili; Frimpong, Leoni, Gomez, Robertson; Nyoni, Endo; Ngumoha, Jones, Chiesa; Isak
• Southampton: McCarthy; Edwards, Wood, Stephens; Rerslev, Fraser, Downes, Charles, Manning; Stewart, Archer

Match facts and head-to-head

• Liverpool has won all six matches this season.
• Southampton has not won five of their last six games.
• Liverpool has won the last four encounters with Southampton.

Prediction

Southampton may try to defend deeply and counter-attack, but the difference in skill and current form is significant. Despite potential rotations in the lineup, Liverpool is expected to dominate the match, creating numerous scoring opportunities.