Manchester City vs Manchester United: Head-to-Head, Line-ups, and Match Prediction for September 14, 2025

In the main event of Premier League Matchday 4, Manchester City will face Manchester United on Sunday, 14 September. The match will kick off at 17:30 Central European Time. Here’s a betting tip for this important game.

See also: Burnley vs Liverpool prediction and betting tips 14 September 2025

Match preview

Manchester City has had a slow start this season, securing just one win in their first three matches. After a victory against Wolverhampton, they lost consecutive games to Tottenham and Brighton, leaving them with three points and in 13th place on the table.

Their challenges began earlier in the summer when they were eliminated from the Club World Cup by Saudi team Al Hilal in the round of 16. As they approach the derby against Manchester United, City is not performing at its best.
Adding to their issues, striker Omar Marmoush is injured and will be out for a period due to his time with the Egypt national team.

Manchester United has also struggled, managing just one win under coach Ruben Amorim, which came in their last match against Burnley. Prior to that, they lost to Arsenal and drew with Fulham.

Their League Cup journey ended poorly, as they were knocked out by League Two team Grimsby on penalties. It has been a tough start for both Manchester clubs, and this upcoming derby could either spark a turnaround or worsen the situation for one team.

Probable line-ups

Manchester City: Donnarumma – Nunez, Dias, Gvardiol, Nouri – Rodri, Silva, Reijnders – Bobb, Doku – Haaland

Manchester United: Bayindir – Yoro, De Ligt, Shaw – Diallo, Casemiro, Mainoo, Dorgu – Mbeumo, Fernandes – Sesko

Match facts and head-to-head

• Manchester United has conceded goals in four straight matches
• The Over 2.5 goals bet has been successful in five of Manchester City’s last six games
• In their last ten meetings, City has won five, United has three wins, and two matches ended in a draw

Prediction

I anticipate a game with plenty of goals: both teams are looking to recover, and their defensive weaknesses may lead to an exciting match. Betting on over 2.5 goals at odds of 1.58 is a strong option.