SSC Napoli vs Pisa: Predictions , Preview, Lineups, H2h for September 23, 2025

On September 22, 2025, Napoli will face Pisa at home for their Serie A match. The game is scheduled to start at 20:45 Central European Time. Here’s a look at the matchup.

Napoli

Napoli, the defending champions, come into this match after a challenging start in the Champions League. They lost 0-2 to Manchester City after receiving an early red card and played most of the game with ten men, marking their first official loss of the season.

In Serie A, Napoli has begun positively with a 2-0 win over Sassuolo, followed by a 1-0 victory against Cagliari, and a 3-1 away win against Fiorentina. Currently, they are at the top of the league with 9 points and a goal difference of 6-1.

At home, Napoli remains unbeaten this year. Historically, they have a strong record against Pisa at home, winning two out of three encounters, with one match ending in a draw.

Pisa

Pisa, newly promoted to Serie A after finishing second in Serie B last season, is yet to secure their first win of the new campaign.

They began their season in the Coppa Italia with a 0-0 draw against Cesena, winning only after penalties. In league play, they managed a 1-1 draw with Atalanta but have since suffered two 1-0 defeats to Udinese and Roma. They currently sit 18th in the standings with just one point.

Pisa has struggled offensively, scoring only once in four official matches. All their games have seen fewer than two goals scored.

In terms of head-to-head, Pisa has never won against Napoli, recording three losses and two draws in five encounters.

Probable lineups

• Napoli: Milinković-Savić, Di Lorenzo, Beukema, Buongiorno, Spinazzola, Lobotka, Politano, De Bruyne, Anguissa, McTominay, Højlund.
• Pisa: Šemper, Lusardi, Caracciolo, Canestrelli, Touré, Marin, Aebischer, Angori, Tramoni, Moreo, Meister.

Key facts and head-to-head stats

• Napoli have won 6 of their last 7 matches.
• They are on a four-game home winning streak.
• Three of their last four matches had under 2.5 total goals.
• Napoli scored first in 6 of their last 7 matches.
• Pisa is winless in 7 consecutive games.
• Their last 5 matches also ended with under 2.5 total goals.

Napoli vs Pisa match prediction

Having started the season strongly, Napoli aims to bounce back after their Champions League disappointment. Meanwhile, Pisa continues to search for their first win. Historically, Napoli has the upper hand in this matchup and is favored to win convincingly. My prediction: Napoli to win with a -1 handicap at odds of 1.43.